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Research indicates that SCD activity may play a key role in melanoma phenotype switching: under low SCD conditions, ER stress is induced, suppresses microphthalmia-associated transcription factor (MITF), and promotes melanoma dedifferentiation (Vivas-Garca et al., 2020)

The reduction of TH activity could be secondary to the degeneration of dopaminergic neurons in PD

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Activation of lung p53 by Nutlin-3a prevents and reverses experimental pulmonary hypertension