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2 Molecular mechanisms of ferroptosis Iron metabolism and LPO (As illustrated in Figure 1A ) as well as ferroptosis defense mechanisms (as shown in Figure 1B ) are the three main molecular mechanisms of ferroptosis

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The passage of the polypeptide into the endoplasmic reticulum (ER) removes the signal peptide, while the nascent IGF-1 prohormone (proIGF-1) is emerging, retaining the E-domain