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27 Another study compared a combination oral supplement that included 600 mg/d ALA along with gamma-linolenic acid to a vitamin supplement containing vitamins B1, B6, and B12 over 3 months in 112 patients with moderate to severe CTS.28 Researchers found similar results, with significant pain reduction and improved function in the ALA treatment group with only slightly improved pain reduction in the vitamin B group but with worsened function

CDCA, CA, DCA, and LCA are all FXR agonists that can activate the FXR-CYP7A1 signaling pathway (80), which inhibits cholesterol consumption and causes abnormal cholesterol levels