tobacco metabolism 1 Major pathways of human nicotine metabolism. Metabolites are 2′-Hydroxylation of nicotine by cytochrome

2 Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: Formation of a lung carcinogen precursor PNAS Figure 5.3, Metabolism of six carcinogens in tobacco smoke that produce DNA adducts identified in the lungs of smokers How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking Attributable BJOC The enzymes of microbial nicotine metabolism People have been smoking tobacco for centuries and getting addicted to the nicotine inside it. Yet we still aren't totally sure where nicotine comes from, or how tobacco plants have the ability Frontiers Integrated metagenomics and metabolomics analysis reveals dynamic changes of microbiota and metabolic profile during fermentation of cigar tobacco (Nicotiana tabacum L.) leaves

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