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It is important to note that current in vitro redox cycling detection is centred on indirect quantification of H 2 O 2 production and O 2 consumption rather than direct measurement of dynamic radical species over time 22,28

Thus, rigorous safety assessments of UA supplementation are essential

Y.KronbichlerA.et al (2019)

For example, due to a genetic mutation that inhibits the synthesis of glutathione starting from its enzyme glutathione synthetase

We are currently conducting a double-blind placebo-controlled trial of 12-month duration which should provide further information on safety and efficacy of NAC in SLE (ClinicalTrials.gov Identifier: NCT00775476)