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In this modification, one of the non-bridging oxygen atoms in the phosphodiester bond is substituted with a sulfur atom (109)

For that group, treating the deficiency is important, because an untreated deficiency does not stay still

However, the longer term measurement (20 hours average) showed a modest but statistically significant increase in blood pressure: a 2.7 mmHg rise in systolic blood pressure and 1.4 mmHg rise in diastolic blood pressure

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