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10.1002/jps.23546 21

Until now, the most important element in disease severity has been the hosts immune response activation or suppression

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Regular measurement of hematologic parameters is recommended in all patients on chronic metformin treatment

In immunosenescent mice, although not showing any statistical difference, the administration of VitE increased the ratio of nave to effector-memory T cells, suggesting that VitE may be effective in restoring oxidative stress-induced immunosenescence (101)