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doi: 10.1111/1541-4337.12898 41 LongYZhangMMujumdarASChenJ

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10.1007/s13277-015-4217-1 Tumour Biol

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This coenzyme supplies the electrons to glutathione reductase, which in turn recycles oxidized GSH via GSSG, to free GSH, which resumes its protective role as a cofactor for antioxidant enzymes in the cell

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CAT has a lower affinity for H 2 O 2 as compared to glutathione-peroxidase (GPx), another enzyme responsible for the degradation of H 2 O 2

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This renal IR evidence is directly pertinent to perioperative AKI risk, particularly in settings featuring transient hypoperfusion or clamp-related ischemia ( Sodium nitrite and Sildenafil are being evaluated for their mitochondria-protective effects via enhancing NO signaling and blood flow, which can reduce reperfusion injury (nitrite can inhibit mitochondrial complex I in a reversible manner to reduce ROS burst on reperfusion)

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