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Prorok PC, Andriole GL, Bresalier RS, Buys SS, Chia D, Crawford ED, et al

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Some investigators have conducted a placebo-controlled phase 3 studies of Edaravone for more than 24 weeks, however, the results showed that Edaravone did not show a significant difference in ALSFRS-R scores compared to placebo, while the post hoc analyses of these data showed that greater effects were demonstrated in the ALS patients who met the specific following enrollment criteria: 2 scores or more on all items of ALSFRS-R, at least 80% of forced vital capacity at baseline, definite or probable ALS diagnosed by El Escorial and revised Airlie House criteria, and the disease duration of 2 years or less (19)

Some patients may need a manometry test, which involves passing a thin, flexible tube through the nose, down the esophagus, and into the stomach to monitor pressure levels

The BSO-induced increased in glutamate shape excitatory transmission