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Jump, R

Clinical relevance of the ACTL6A-GCLC-GSH metabolism axis in ferroptosis of GC cells Next, we sought to determine the clinical relevance of ACTL6A in regulating GCLC and inhibiting ferroptosis in a patient-derived xenograft (PDX) model

The findings demonstrate that both exercise and polyphenols independently contribute to mood enhancement, reduced anxiety, and improved cognitive function through mechanisms such as neurogenesis, neurotransmitter modulation, and anti-inflammatory effects

doi: 10.1016/s0301-0082(00)00031-9 153 RussoEB

Glutathione (GSH) is the most abundant free soluble thiol of low molecular weight, serving key roles in redox buffering under oxidative stress, ISC biosynthesis, and detoxification of ROS 7,8,9,10