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doi: 10.1016/0005-2760(92)90237-P

PI3K inhibitors, such as 3-methyladenine (3-MA), wortmannin, and LY294002, target autophagy by inhibiting Vps34, a component of class III PI3K, thereby blocking the formation of autophagosomes [96]

This would contradict the hypothesis of the role of peroxynitrite as the key oxidant in APAP pathophysiology and would also be inconsistent with the limited LPO