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This polymorphism impairs the lipase activity of adiponutrin and impairs TG hydrolysis, leading to an accumulation of TG in hepatocytes and consequently to steatosis

While HE staining showed no overt inter-group differences, RT-qPCR analysis revealed a significant downregulation of genes associated with the intestinal barrier (ZO-1, Occludin, Claudin-1, Claudin-4) in the Model group compared to the Control group

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Angiogenic effect was evaluated by counting the number of the tubule branching on 5 visual fields (microscope objective x 20) (modification of Jones RA, 18)