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During the replication fork progression, TIMELESS forms a complex with TIPIN in the replisome to facilitate the progression of DNA replication fork 17,39,40

D., Bremner, D

On the other hand, a vitamin B12 deficiency appears to cause a loss of appetite in some people, leading to weight loss rather than weight gain ( That said, the current evidence is too weak to suggest that a vitamin B12 deficiency has any strong or specific impact on weight be it weight gain or loss

Weight loss is a gradual process

This makes the fragment a useful reference in studies designed to isolate lipolytic endpoints from GH-axis side effects