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Additionally, whole tissue lysates were prepared from four discarded human steatotic livers deemed unsuitable for transplant

79 Moreover, 50% of the samples were considered marginally deficient in copper, with 14% classified as critically deficient

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Observational cohorts are further confounded by smoking, obesity, socioeconomic status, healthcare access, HBV viral load, antiviral treatment, and other hepatotoxic exposures

For example, monocyte chemoattractant protein-1 recruits immune cells to the injured area for targeted inflammation regulation (Chen et al., 2017a), whereas Interleukin (IL)-6 and IL-8 stimulate proliferative pathways in hepatic cells and promote the recruitment of neutrophils and macrophages, thereby enhancing tissue repair (Qiu et al., 2012