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The RSPCA believes that, wherever animals are being considered for use in research, the humane research principles of replacement (non-animal alternatives to be used), reduction (minimum number of animals used) and refinement (procedures to minimise pain and suffering are implemented), known as the Three Rs [4], must be adhered to

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Patients and carers should be aware of this risk

Eli James EJ Hotaling is the first child in the US to die from accidentally swallowing the toxic ingredient in e-cigarettes