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As a consequence, they encountered increased pain and swelling, requiring additional medical attention and a lengthened recovery period

[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head

Patients should receive clear instructions regarding symptoms or changes that should prompt immediate medical evaluation, and healthcare providers should maintain heightened vigilance for potential adverse effects

FIGURE 3 Overall, the ligand-based pharmacophore models present strength in terms of high recall and ROC AUC values, suggesting their potential utility in identifying novel active compounds