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It has also been documented that the combined use of QE with rosuvastatin reduced the intensity of oxidative stress and enhanced antioxidant protection activity, resulting in a decrease in apoptosis of hepatocytes (cytokeratin-18 level was 1.27 times decreased), and prevented the development and progression of metabolic disorders associated with NAFLD (Kravchenko et al., 2024)

It was found in a hyperuricemic kidney injury study found that modulating M1 macrophages dampened the inflammatory response (71)

2 Next-generation redox-adaptive nanoplatforms: insights from recent breakthrough studies Recent work has rapidly advanced organelle-targeted, microenvironment-activated nanomedicines that directly intersect with glutathione (GSH)-responsive sensing and therapeutics Table 1