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Acknowledgments We thank the UK Biobank study, and the summary statistics data of UKB can be download from Neale lab ( and other GWAS summary-level data, which have been downloaded from We also thank all the reviewers and editors for their useful suggestions for improving this study

Most patients begin noticing reduced cravings and improved appetite control within 12 weeks, with visible weight-loss results typically appearing around 46 weeks

It is not approved for human use, clinical treatment, or athletic performance

Best of all, no pain

That decision is made in consultation, based on the individual patients labs, history, and goals