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Reactive oxygen species can oxidize and directly enhance CaMKII activity, which in turn phosphorylates and activates several Ca 2+ -handling proteins such as the cardiac ryanodine receptor RyR2 or cardiac SERCA (50)

Interestingly, clinical features (disease duration or severity) and PD medication use were not associated with tdc gene abundance, supporting the potential use of relative abundance of bacterial tdc gene as a biomarker of levodopa responsiveness before treatment initiation [39]

At the level of microcircuits, this could be studied, e.g., by comparison of plasticity in feed-forward vs

[257]. Q.Y