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For patients with obesity, type 2 diabetes, or significant metabolic syndrome, GLP-1 medications have strong evidence and meaningful clinical outcomes

Science 321 , 13151322 (2008)

FDA noted that reviewed CoAs from suppliers did not consistently include controls for impurities, aggregates, or bacterial endotoxins

However, its still important to be aware of potential interactions

Therefore, when semaglutide is used for weight management, administer with caution in patients with depression and avoid use in patients with a history of suicide attempts or active suicidal ideation