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The patient also reported a reduction in Raynaud phenomenon symptoms ( In another case study, a patient with Scl70+ SSc and nonspecific interstitial pneumonia (NSIP) received third-generation CD19-CAR-T ( Recently, a short-term follow-up study was conducted on two SSc patients who received allogeneic CD19 CAR-T therapy ( Long-term follow-up of 4 SSc patients, including the aforementioned 60-year-old patient, demonstrates the efficacy of CD19 CAR-T therapy

Recently, Chen and colleagues developed a SAD cortical organoid model from human iPSCs and exposed it to serum to mimic BBB breakage, a common AD feature, and observed increased A-like pathology, hyperphosphorylated tau, synaptic loss, and an impaired neural network [191]