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The following additional adverse reactions were reported by greater than 1% but not more than 5% of the Depakote ER-treated patients in controlled clinical trials: Body as a Whole: Back Pain, Flu Syndrome, Infection, Infection Fungal Cardiovascular System: Hypertension Digestive System: Constipation, Dry Mouth, Flatulence Hemic and Lymphatic System: Ecchymosis Metabolic and Nutritional Disorders Peripheral Edema Musculoskeletal System: Myalgia Nervous System: Abnormal Gait, Hypertonia, Tremor Respiratory System: Rhinitis Skin and Appendages: Pruritus, Rash Special Senses: Conjunctivitis Urogenital System: Urinary Tract Infection, Vaginitis Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity

Post-mortem brain tissues of BD patients also revealed higher levels of HNE-4 compared to nonpsychiatric, non-neurologic controls [154]

Renal histopathology and crystal deposits in patients with small bowel resection and calcium oxalate stone disease

Felt better day 3, but still tired

Practically all body fluids, including breast milk, contain melatonin