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De Smedt A, Brouns R, Uyttenboogaart M, De Raedt S, Moens M, Wilczak N, Luijckx GJ, De Keyser J: Insulin-like growth factor I serum levels influence ischemic stroke outcome

Resveratrol induced similar transcription profiles as SIRT1 and CR and promoted the same protective effects in heart, skeletal muscle and brain tissue in mice where it also prolonged lifespan and prevented age-related cardiac dysfunction (231)

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By activating soluble guanylate cyclase (sGC), NO elevates cyclic guanosine monophosphate (cGMP) levels, which relaxes smooth muscle and facilitates vasodilation (Wu et al., 2021)