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We update protocols when new clinical trial data publishes (for example, when TRIUMPH Phase 3 readouts update the retatrutide protocol), when regulatory status changes (the February 2026 FDA Category 2 reclassification affected multiple compound pages), or when reconstitution math needs correction

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In hepatocytes and adipocytes it reduces the activity of key lipogenic enzymes: Acetyl-CoA carboxylase (ACC) , a key step in fatty acid synthesis Fatty acid synthase (FAS) , the enzyme creating long chains of fatty acids Lipoprotein lipase (LPL) in adipocytes, reduces uptake of circulating triglycerides into fat cells Imagine it as turning valves in a pipeline, you close the inflow (lipogenesis), open the outflow (lipolysis)