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Pfizer and Moderna were originally developing boosters to target omicron BA.1, the variant that caused the massive wave of infection last winter

In our analysis of residues located within the central cavity, point mutants R143A/E/K were constructed

These effects can be explained by the activation of strong defense responses in these mutants, including the suberinization of infection thread walls in sym33-3 nodules ( sym40-1 nodules (Tsyganova et al., 2009)

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For this analysis, the datasets for the three timepoints (1, 6, and 20 months) were processed independently and were not integrated prior to UMAP visualization