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GSTA4 levels are reduced in adipose tissue of obese human and mice (131) and Gsta4 knockout 129/sv mice show increased malonyl-CoA expression, mitochondrial dysfunction and obesity, contributing to development of insulin resistance (131, 132) and the microsomal glutathione transferase 1 (MGST1) plays a key role in regulating ferroptosis-mediated -cell dysfunction in T2D and in diabetic cardiomyopathy (133, 134)

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