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Importantly, distinctions must be drawn between hereditary CRC syndromes, sporadic CRC (arising through the adenomacarcinoma sequence), and inflammatory bowel disease (IBD)-associated CRC, as each clinical setting may involve distinct pathways influenced by vitamin D status, perhaps in different ways [54]

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However, they do not clearly slow disease progression and often cause gastrointestinal (GI) side effects like nausea, diarrhea, and vomiting [28]

In fact, in zinc deficient-obesity, leptin rise promoted the increase in macrophage infiltration in adipose tissue of mice fed a high-fat diet (108)

Most recently, advancements have also been made in the differentiation of mouse embryonic stem cells (mESCs) toward neuroectoderm and neural progenitor cells [144]