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It is generally advised to avoid Botox if you are pregnant or breastfeeding

By sticking to established, safe administration protocols like subcutaneous injection and prioritizing the purity of your research compounds, you create the best possible conditions for gathering clear, meaningful, and reproducible data

In addition, a recently published study by Matei et al

It is also a zwitterion, a neutral molecule with a positive and negative end

Note that these are also not pharmacological treatments, but they are worth mentioning as options for patients with comorbidities or contraindications for other pharmacological treatments