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Following cleavage by furin (between residues R307 and S308), pro-c-MET is converted into a mature heterodimer (mature c-MET) composed of an extracellular -chain and a single-pass transmembrane -chain linked by disulfide bonds [2][3]

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In addition, it has now been demonstrated to have beneficial effects on musculoskeletal soft tissue injuries and gastrointestinal tract lesions or lesions in the liver, two non-healing wounds that significantly impact health and disease

10.1371/journal.pgen.1000020 45 PfannenstielS.PraetoriusM.PlinkertP.BroughD.StaeckerH