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489 In families affected by XLID, a number of loss-of-function mutations were found in the GDI1 gene, 490 which encodes a cytosolic protein GDI, the RAB GDP dissociation inhibitor, involved in the control of the guanosine diphosphate (GDP)-bound form of the brain RAB GTPases 491,492 and regulates vesicle dynamics

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[15] Inside the lysosome, transcobalamin is degraded and free cobalamin is exported to the cytosol, where a trafficking and processing protein encoded by MMACHC (with a partner encoded by MMADHC ) strips off whatever upper-axial ligand the incoming cobalamin carried cyanide, hydroxyl, methyl, or adenosyl and reduces the cobalt center

Stress Management Chronic stress can deplete your body's antioxidant levels