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Regarding that a certain number of medicines in TCM has been shown to be anti-depressive [147]

This process also triggers the release of proapoptotic factors ( Multiple research studies have indicated a correlation between the suppression of p53 and the avoidance of apoptosis by both malignant and pre-malignant cells, resulting in the beginning and the advancement of tumorigenesis (Yamamoto et al., 1999)

ThungIAraminHVavinskayaVGuptaSParkJYCroweSEet al

In addition, studies aiming at establishing dose-response relationships of (1) ATZ on CYP19A1 induction/activity, (2) curcumin on ATZ detoxification with ATZ plasma level as the outcome measure, and (3) curcumin on counteracting ATZs promoting effect on breast cancer development with breast tissue proliferation index as the endpoint would be extremely valuable in supporting curcumin as a mechanism-based antidote for ATZ exposure

Opioids activate our mu-receptors, which influence the sensations of both pain and pleasure