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The concentration of the conjugate of the invention in the pharmaceutical composition can vary widely, i.e., from less than about 0.1% by weight, usually being at least about 1% by weight to as much as 20% by weight or more

Further, high glucose sensitizes HepG2 cells towards apoptosis [18] and induces the expression of CYP2E1 in VL-17A cells [21]

All of these are normal variations from the manufacturing process

The resultant increased levels of the chemokines and other proinflammatory reactions, are thought to contribute to tubule-interstitial disease (Qian et al., 2010), decreased renal perfusion and intra-tubular casts formed by the interaction of heme proteins with Tamm-Horsfall protein (Tracz et al., 2007)

2A-B), PDI of 0.031, and surface charge of + 34.5 7.1 mV (Fig