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202 A small pilot trial involving 15 fibromyalgia patients found tender point index scores decreased after an average of eight weeks of supplementation with 300600 mg of magnesium plus 1,2002,400 mg of malic acid daily and increased after two weeks of placebo

Glutamate plays a critical role in neuronal migration and plasticity by being an excitatory neurotransmitter, and an excess of glutamate is expected to result in the excitotoxicity-induced apoptosis of neurons

The up-regulation of glutamate and glycine in response to 5-oxp was more pronounced under heat stress relative to their responses to 5-oxp under non-stress conditions

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Additionally, studies have revealed that the proportions of phosphorylated GSK-3 and overexpressed -catenin in HCC tissues are 52.2% and 56.5%, respectively, higher than in surrounding normal tissues