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The canonical NK-B signaling pathway can be induced by extensive numbers of stimuli including Toll-like receptor ligands, proinflammatory cytokines [e.g., tumor necrosis factor (TNF-)], and antigens, leading to the activation of IKK complex, which comprises IKK (IKK1), IKK (IKK2), and NF-B essential modulator (NEMO, also known as IKK)

Vavvas et al., 2018)

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Diffusion tensor imaging of white matter involvement in essential tremor

380 Another primary astrocytopathy linked to dysregulated iron homoeostasis is aceruloplasminemia, an autosomal recessive neurodegenerative disease caused by a loss of function mutations of the gene encoding ceruloplasmin, an enzyme that converts ferrous iron to ferric