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In very select, treatment-resistant cases, deep brain stimulation (targeting specific regions of the thalamus) or motor cortex stimulation (placing electrodes on the surface of the brain over the motor cortex) has been investigated as a neuromodulation option

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In humans the data is almost nothing: two small Croatian trials using BPC enemas for ulcerative colitis, never fully published

For more substantial or chronic conditions (e.g., tendon injuries or longstanding inflammation), treatments may last 46 weeks to see full or peak effects, and some individuals may require longer cycles for maximal benefit

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