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[] DMSA is a dithiol chelating agent with the lowest toxicity level among the common chelating agents used clinically

This intracellular PAF C-16 can bind to its nuclear receptors and elicit various signaling pathways resulting in the expression of proinflammatory genes such as iNOS and COX-2 (Zhu et al., 2006)

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To obtain the specific labeling patterns, intracellular metabolites were extracted and analyzed using GC/MS to determine multiple ion detections (MIDs) (corrected for natural isotope abundance), which reflect relative metabolic fluxes 28

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