The past years have seen significant progress in the development of GLS inhibitor, BPTES, as a promising drug candidate by researchers
TXN helps modulate the activity of many transcription factors through oxidoreductive modification of the protein
In aquaculture, beneficial feed additives such as probiotics and prebiotics are utilized to stimulate growth, enhance immunity to combat diseases, and provide alternative antimicrobial solutions ( According to Wee et al
According to the results of studies revised and discussed in this paper, we identify the following highlights: (i) The low solubility and poor bioavailability of I3C and DIM limit their use as a medical treatment, so it is necessary to increase the research regarding pharmaceutic forms that improve these parameters, (ii) I3C and DIM have pro-apoptotic and antiproliferative effects and inhibit cell growth in pre-clinical and clinical cancer assays (Tables 2 and 3), (iii) Since I3C and DIM derivatives such as 5,5-Br2-DIM, the regulated cellular process associated with hallmarks of cancer, it could be essential to evaluate also these derivatives as anti-cancer agents, maybe in conjunct with DIM or I3C, and finally, (iv) The current evaluation of the anti-tumoral activities of DIM and I3C is generally based on mechanisms involving signalizing ways such as NF- B, Akt, Wnt, PI3K/Akt/mTOR, and AhR
CY: Data curation, Writing review & editing
