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ROS can directly activate the NF-kB transcription factor pathway, promoting the synthesis of inflammatory cytokines (85)

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Infusion products with a high content of early memory CAR-T cells display superior expansion, anti-tumor response, and in vivo persistence [23, 24, 44, 46,47,48,49]

It is also an important thiol buffer, maintaining sulfhydryl groups in their reduced form, an additional mechanism for cellular signaling

The Schilling test, which was developed in 1953, relied on radiolabeled cobalamin to track defects in absorption