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10.1021/ja075557u

Results: Both peptides increased proinflammatory cytokine secretion by unstimulated RAW 264.7 macrophages and these effects were blocked by the NF-B cascade inhibitor, stress-activated protein kinase (SAPK)/JNK cascade inhibitor and, to a lesser extent, Toll-like 4 receptor activity inhibitor

In response to oxidative stress, NRF2 is released and translocated to the nucleus, where it can trans-activate androstane receptor (CAR) signaling, which in turn, activates downstream anti-oxidative targets implicated in glutathione antioxidant system (Chan et al., 2001

Exercise can also improve the synchrony of activity within auditory-related brain networks (Rajab et al., 2014)

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