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During Covid, there was a research paper written

Additionally, elderly individuals may have reduced stomach acid production, affecting their ability to absorb B12 from food sources

Long half-life (characterized in studies): Reported as long-acting in preclinical and clinical research, supporting extended-interval dosing within those study protocols

Mayo Clinic suggests that of heavy drinkers, 10%20% develop cirrhosis, a serious condition that usually develops after 10 or more years of drinking. cirrhosis does not develop below a lifetime alcohol consumption of 100 kg of undiluted alcohol

Not as an independent driver of weight loss the evidence for that is weak