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Cells treated with test compounds were washed with PBS and incubated with 10 M 2,7-dichlorofluorescein diacetate (DCFH-DA) at 37 C for 30 min, followed by washing with PBS, digestion with trypsin, and collection

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Gene set enrichment analysis (GSEA) was performed to identify gene ontology terms and pathways associated with differential gene expression

Cisplatin is a common and widely used medication that has successfully increased the cure rate of a range of cancers, including breast, lung, brain and testicular cancers, but it is not without an array of side effects from nausea to kidney failure