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doi: 10.1073/pnas.1014697108

During a Beverly Hills consultation, Dr

Nature 423 , 720724 (2003)

doi: 10.1074/jbc.REV119.007363 429 McMillanACWhiteMD

Strengthening the endogenous C5 pathway by sequentially knocking out the negative regulatory protein gene hemX , overexpressing the endogenous glutamyl-tRNA reductase gene hemA , and knocking out the glutamate dehydrogenase gene rocG , increased the heme production by 427%