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Editorial: cellular mechanisms of ototoxicity

Over-Dilution: Leads to a lower concentration than intended, which can result in inaccurate dosing

While herbal medicines pose negative impacts, such as limiting efficacy and increasing toxicity of ACDs, they also offer potential benefits, including enhancing bioavailability, reducing adverse reactions, and reversing tumor drug resistance

Similarly, in PDAC, co-administration of dihydroartemisinin (DHA) and cisplatin enhances cytotoxicity through the ferroptosis pathway (Song et al., 2021)