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As is typical for many toxicology interventions, there may never be a randomized controlled trial

In a larger crossover study involving 84 healthy adults, daily consumption of 100 g fresh or pasteurized sauerkraut for 4 weeks produced no significant changes in overall gut microbial composition, as assessed by shotgun metagenomic sequencing (Schropp et al., 2025)

Growth and neurotrophic factors CSF Brain Derived Neurotrophic Factor (BDNF) levels have been found to be similar in PD patients with major depression to those in patients with major depression without PD in one study (Plhagen et al., 2010), while another described this value as increased in PD patients compared with controls (Salehi and Mashayekhi, 2009)

doi: 10.1016/j.kint.2020.10.038

Curr Diabetes Rep 18(6):33