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In conclusion, while testosterone- and SARMs-based therapies hold significant promises for sarcopenia treatment, their clinical adoption requires further refinement

Svenningsson et al., 2013

Due to hyperinflation and long-term unfavourable mechanical position, the diaphragm is forced to remain in a state of contraction, which is easy to cause the decline of diaphragm compliance and contraction force, leading to diaphragm fatigue (McKenzie et al., 2009) (Figure 1)

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