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Incoorating into genetic vaccines one or more components that inhibit peptide transport and/or MHC class I expression in order to obtain viral vectors that are capable of escaping a host CTL immune response In one embodiment, the invention provides methods of obtaining viral vectors that are capable of escaping a host CTL immune response

J Neurol Sci 170:138146 Hussinger D, Dhiman RK, Felipo V, Grg B, Jalan R, Kircheis G, Merli M, Montagnese S, Romero-Gomez M, Schnitzler A, Taylor-Robinson SD, Vilstrup H (2022) Hepatic encephalopathy

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Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI (2024) Restoring hippocampal glucose metabolism rescues cognition across Alzheimers disease pathologies