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Four populations were identified: viable (Annexin/PI), early apoptotic (Annexin+/PI), late apoptotic (Annexin+/PI+), and necrotic (Annexin/PI+)

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Focus on mammalian thioredoxin reductasesimportant selenoproteins with versatile functions

Hormesis the role of recovery and stress adaptation Hormesis represents the positive and beneficial physiological effects of exposing yourself to various mild stressors and toxins

Mechanistic investigations have implicated oxidative stress, inflammatory responses, and apoptosis as critical components in the etiology of CP-induced POF, although the exact process by which this ovarian toxicity occurs remains unclear