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Sestrin2 plays a protective role in AD by mitigating Ang II-induced VSMC cell apoptosis through the Nrf2 pathway (161)

Multiple mechanisms are responsible for the anemia, but the main mechanisms are decreased RBC production due to suppression of erythropoiesis, reduced iron availability, and decreased RBC lifespan (extravascular hemolysis)

These tremendous numbers will continue to grow due to an aging population, with the rise of life expectancy worldwide

This enables the development of more effective ADC therapies, especially for cancers with immune evasion mechanisms [368, 369]

Chronic altitude illness CMS Unlike acute altitude illnesses, research on the genetic basis of CMS is limited, with only a few studies exploring the link between CMS susceptibility and several genes, including SENP1 , ACE , AGT , and VEGFA (Table 1)