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2361-C PREVALENCE OF INTRANUCLEAR LIPID DROPLETS IN NONALCOHOLIC FATTY LIVER DISEASE Norihiro Imai 1 , Yuki Ohsaki 2 , Jinglei Cheng 1 , Jingjing Zhang 1 , Fumitaka Mizuno 1 , Taku Tanaka 1 , Shinya Yokoyama 1 , Kenta Yamamoto 1 , Takanori Ito 1 , Yoji Ishizu 1 , Takashi Honda 1 , Masatoshi Ishigami 1 , Hiroaki Wake 1 and Hiroki Kawashima 1 , (1)Nagoya University Graduate School of Medicine, (2)Sapporo Medical University Background: Lipid droplets (LDs) are organelles found in not only adipocytes but also various cells throughout the body, and they store excess energy while also fulfilling a multitude of physiological functions

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PS increased insulin resistance through lncRNA expression and Erk1/2 phosphorylation in the adipocyte To further clarify the mechanism underlying the effect of PS on insulin resistance observed in KKAY model ( Fig

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