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Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, et al

Interfaces 13 , 1292812940 (2021)

Among the reasons for the weak response in clinical results are the length of time, cost, and complexity of nanomedicine technology compared to traditional formulation technology, which relies on easy treatment in the form of appropriate doses (whether capsules, tablets, or injections) [179]

Notably, under BSO treatment, these molecules may increase cysteine availability but should not restore GSH levels, as BSO irreversibly inhibits -glutamylcysteine synthetase (-GCS) the enzyme responsible for GSH synthesis downstream of cysteine 48